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ChroNOline ™

August 19, 2020

What is chronoline?

ChroNOline™ is a biomimetic lipopeptide also known as caproyl tetrapeptide-3, comprising four amino acids linked to a lipid (caproic acid). It is derived from a growth factor known as TGF-ß.

 In-vitro testing has demonstrated that ChroNOline stimulates the production of laminin, fibronectin and collagen VII, vital components of the dermo-epidermal junction. Laminin-5 is a glycoprotein that anchors the epidermis to the dermis.

 By protecting and restoring the cell-matrix interactions associated with cellular turnover and regeneration, ChroNOline encourages skin’s natural repair processes and minimises the visible signs of ageing, including fine lines and wrinkles. ChroNOline is also used to treat stretch marks and acne scars.

Benefits of chronoline

1. Significant and sustained reduction of fine lines and wrinkles

ChroNOline is shown to increase production of collagen-3 by 34 percent, laminin by 26 percent and laminin-5 by 49 percent. By stimulating laminin and fibronectin production, ChroNOline helps to promote optimal cell function and maintain the integrity of the dermo-epidermal junction. In a clinical trial, ChroNOline reduced fine lines and wrinkles by as much as 29 percent after 28 days.

2. Reduced appearance of stretch marks

When applied to the body, ChroNOline was shown to reduce the appearance of stretch marks, improve skin tone and promote smoothness and elasticity. Subjects in a recent study noted visible results after just 4 weeks. After 8 weeks, 68 percent of subjects reported that their stretch marks appeared less dilated and diffused.

3. Smoothing and toning skin

In the same study, the majority of subjects observed that their skin was suppler, smoother and more elastic after 4 weeks of regular application. They also noted a significantly improved skin tone and texture.

Is chronoline suitable for my skin type? 

ChroNOline is recommended for all skin types, especially mature or sensitive skin types. It is gentle enough to use on the delicate skin in the eye area.

Can chronoline be used alongside other products?

ChroNOline works well in combination with other products. It is safe for use alongside other key actives such as polyhydroxy acids.

How often should I apply chronoline?

ChroNOline can be used twice a day. Apply a product containing ChroNOline to thoroughly cleansed skin in the morning and at night.